A Road Map to Personalizing Targeted Cancer Therapies Using Synthetic Lethality.

Parameswaran, Sreejit; Kundapur, Deeksha; Vizeacoumar, Frederick S; Freywald, Andrew; Uppalapati, Maruti; Vizeacoumar, Franco J

Parameswaran, Sreejit; Kundapur, Deeksha; Vizeacoumar, Frederick S; Freywald, Andrew; Uppalapati, Maruti; Vizeacoumar, Franco J.

Afiliación

Parameswaran S; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, S7N 5E5, Canada; These authors contributed equally.
Kundapur D; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, S7N 5E5, Canada; These authors contributed equally.
Vizeacoumar FS; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, S7N 5E5, Canada.
Freywald A; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, S7N 5E5, Canada. Electronic address: andrew.freywald@usask.ca.
Uppalapati M; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, S7N 5E5, Canada. Electronic address: maruti.uppalapati@usask.ca.
Vizeacoumar FJ; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, S7N 5E5, Canada; Cancer Research, Saskatchewan Cancer Agency, 107 Wiggins Road, Saskatoon, S7N 5E5, Canada. Electronic address: franco.vizeacoumar@usask.ca.

Trends Cancer ; 5(1): 11-29, 2019 01.

Article en En | MEDLINE | ID: mdl-30616753

Asunto(s)

Terapia Molecular Dirigida; Neoplasias/tratamiento farmacológico; Neoplasias/genética; Medicina de Precisión; Mutaciones Letales Sintéticas; Animales; Antineoplásicos/farmacología; Antineoplásicos/uso terapéutico; Biomarcadores de Tumor; Sistemas CRISPR-Cas; Edición Génica; Heterogeneidad Genética; Humanos; Terapia Molecular Dirigida/métodos; Neoplasias/metabolismo; Neoplasias/patología; Medicina de Precisión/métodos; ARN Interferente Pequeño/genética; Transducción de Señal

Palabras clave

shRNA vs CRISPR; synthetic lethality; targeting intracellular molecules

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Medicina de Precisión / Terapia Molecular Dirigida / Mutaciones Letales Sintéticas / Neoplasias Límite: Animals / Humans Idioma: En Revista: Trends Cancer Año: 2019 Tipo del documento: Article

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