Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4<sup>+</sup> T-cell development and allergic airway disease.

Patterson, Andrew R; Bolcas, Paige; Lampe, Kristin; Cantrell, Rachel; Ruff, Brandy; Lewkowich, Ian; Hogan, Simon P; Janssen, Edith M; Bleesing, Jack; Khurana Hershey, Gurjit K; Hoebe, Kasper

Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4⁺ T-cell development and allergic airway disease.

Patterson, Andrew R; Bolcas, Paige; Lampe, Kristin; Cantrell, Rachel; Ruff, Brandy; Lewkowich, Ian; Hogan, Simon P; Janssen, Edith M; Bleesing, Jack; Khurana Hershey, Gurjit K; Hoebe, Kasper.

Afiliación

Patterson AR; Division of Immunobiology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio.
Bolcas P; Division of Asthma Research, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio.
Lampe K; Division of Immunobiology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio.
Cantrell R; Division of Immunobiology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio.
Ruff B; Division of Asthma Research, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio.
Lewkowich I; Division of Immunobiology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Hogan SP; Division of Immunobiology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Janssen EM; Division of Immunobiology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Bleesing J; Division of Bone Marrow Transplantation & Immune Deficiency, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio.
Khurana Hershey GK; Division of Asthma Research, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Hoebe K; Division of Immunobiology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: khoebe@its.jnj.com.

J Allergy Clin Immunol ; 143(1): 245-257.e6, 2019 01.

Article en En | MEDLINE | ID: mdl-30616774

Asunto(s)

Asma/inmunología; GTP Fosfohidrolasas/deficiencia; Mutación con Pérdida de Función; Células Th17/inmunología; Células Th2/inmunología; Animales; Asma/genética; Asma/patología; GTP Fosfohidrolasas/inmunología; Proteínas de Unión al GTP; Humanos; Ratones; Ratones Transgénicos; Células Th17/patología; Células Th2/patología; Factor de Crecimiento Transformador beta/genética

Palabras clave

Allergic airway disease; DNA damage response; GIMAP5; T(H)2/T(H)17 cells; T-cell polarization; TGF-ß; house dust mite; immune homeostasis; lung disease; primary immune deficiency

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Asma / Células Th2 / Células Th17 / Mutación con Pérdida de Función / GTP Fosfohidrolasas Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Allergy Clin Immunol Año: 2019 Tipo del documento: Article

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