Your browser doesn't support javascript.
loading
Synthesis of Benzofuran Derivatives through Cascade Radical Cyclization/Intermolecular Coupling of 2-Azaallyls.
Deng, Guogang; Li, Minyan; Yu, Kaili; Liu, Chunxiang; Liu, Zhengfen; Duan, Shengzu; Chen, Wen; Yang, Xiaodong; Zhang, Hongbin; Walsh, Patrick J.
Afiliación
  • Deng G; Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education and Yunnan Province, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
  • Li M; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA, USA.
  • Yu K; Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education and Yunnan Province, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
  • Liu C; Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education and Yunnan Province, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
  • Liu Z; Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education and Yunnan Province, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
  • Duan S; Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education and Yunnan Province, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
  • Chen W; Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education and Yunnan Province, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
  • Yang X; Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education and Yunnan Province, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
  • Zhang H; Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education and Yunnan Province, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
  • Walsh PJ; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA, USA.
Angew Chem Int Ed Engl ; 58(9): 2826-2830, 2019 02 25.
Article en En | MEDLINE | ID: mdl-30624843
ABSTRACT
Benzofurans are among the most popular structural units in bioactive natural products, however, the synthesis of such structures by radical cyclization cascade reactions is rare. Herein, we report a mild and broadly applicable method for the construction of complex benzofurylethylamine derivatives through a unique radical cyclization cascade mechanism. Single-electron transfer (SET) from 2-azaallyl anions to 2-iodo aryl allenyl ethers initiates a radical cyclization that is followed by intermolecular radical-radical coupling. This expedient approach enables the synthesis of a range of polycyclic benzofurans that would otherwise be difficult to prepare.
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2019 Tipo del documento: Article