[Single-center retrospective analysis of extracorporal photopheresis in clinical practice : Peripheral venous compared to central venous access]. / Unizentrische, retrospektive Analyse der praktischen Durchführung der extrakorporalen Photopherese : Periphervenöser und zentralvenöser Zugang im Vergleich.
Hautarzt
; 70(3): 193-203, 2019 Mar.
Article
en De
| MEDLINE
| ID: mdl-30627743
ABSTRACT
BACKGROUND:
Extracorporal photopheresis (ECP) was shown to be effective without severe side effects in the treatment of cutaneous T cell lymphoma (CTCL) and graft versus host disease (GvHD). However, only few studies investigated the practical aspects of ECP.METHODS:
Treatment protocols of 2038 ECP procedures in 52 patients (CTCL, nâ¯= 29; GvHD, nâ¯= 15; other, nâ¯= 8) were evaluated. The patients were treated with the UVAR® XTS™ ECP system (Therakos, Inc. Johnson & Johnson, Raritan, NJ, USA) between 2001 and 2010. All patients started with a peripheral venous access. During the course of treatment 7 patients were treated via a port and 4 via a central venous catheter.RESULTS:
In all, 1765 (86.6%) treatments were performed with a peripheral venous access; 239 (11.7%) ECPs were done via a port and 34 (1.7%) via a central venous catheter. The peripheral venous access showed a higher flow rate and longer photoactivation time. ECPs via port lead to higher UV-irradiated volumes, longer treatment times and higher differences in systolic blood pressure. The following side effects were observed being unwell (nâ¯= 13), hypo- (nâ¯= 13) and hypertension (nâ¯= 7), vertigo (nâ¯= 4), headache (nâ¯= 4), shortness of breath (nâ¯= 4), fever (nâ¯= 3) and metallic taste (nâ¯= 3). Technical complications such as problems with venous access (9.6%) occurred in 385 (18.9%) treatments.CONCLUSIONS:
Peripheral venous access should be preferred for ECP treatments.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cateterismo Venoso Central
/
Cateterismo Periférico
/
Linfoma Cutáneo de Células T
/
Fotoféresis
/
Enfermedad Injerto contra Huésped
Tipo de estudio:
Guideline
/
Observational_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
De
Revista:
Hautarzt
Año:
2019
Tipo del documento:
Article