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Enhanced Activity of Enzymes Encapsulated in Hydrophilic Metal-Organic Frameworks.
Liang, Weibin; Xu, Huoshu; Carraro, Francesco; Maddigan, Natasha K; Li, Qiaowei; Bell, Stephen G; Huang, David M; Tarzia, Andrew; Solomon, Marcello B; Amenitsch, Heinz; Vaccari, Lisa; Sumby, Christopher J; Falcaro, Paolo; Doonan, Christian J.
Afiliación
  • Liang W; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Xu H; Department of Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials , Fudan University , Shanghai 200433 , P.R. China.
  • Maddigan NK; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Li Q; Department of Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials , Fudan University , Shanghai 200433 , P.R. China.
  • Bell SG; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Huang DM; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Tarzia A; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Solomon MB; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Vaccari L; Elettra-Sincrotrone Trieste S.C.p.A, S.S. 14 Km 163,5 in AREA Science Park , 34149 , Basovizza, Trieste , Italy.
  • Sumby CJ; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Falcaro P; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
  • Doonan CJ; Department of Chemistry and the Centre for Advanced Nanomaterials , The University of Adelaide , Adelaide , South Australia 5005 , Australia.
J Am Chem Soc ; 141(6): 2348-2355, 2019 02 13.
Article en En | MEDLINE | ID: mdl-30636404
ABSTRACT
Encapsulation of biomacromolecules in metal-organic frameworks (MOFs) can preserve biological functionality in harsh environments. Despite the success of this approach, termed biomimietic mineralization, limited consideration has been given to the chemistry of the MOF coating. Here, we show that enzymes encapsulated within hydrophilic MAF-7 or ZIF-90 retain enzymatic activity upon encapsulation and when exposed to high temperatures, denaturing or proteolytic agents, and organic solvents, whereas hydrophobic ZIF-8 affords inactive catalase and negligible protection to urease.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enzimas Inmovilizadas / Interacciones Hidrofóbicas e Hidrofílicas / Estructuras Metalorgánicas Idioma: En Revista: J Am Chem Soc Año: 2019 Tipo del documento: Article País de afiliación: Australia
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enzimas Inmovilizadas / Interacciones Hidrofóbicas e Hidrofílicas / Estructuras Metalorgánicas Idioma: En Revista: J Am Chem Soc Año: 2019 Tipo del documento: Article País de afiliación: Australia