Copper-Catalyzed Asymmetric Arylation of N-Heteroaryl Aldimines: Elementary Step of a 1,4-Insertion.

Wu, Chunlin; Qin, Xurong; Moeljadi, Adhitya Mangala Putra; Hirao, Hajime; Zhou, Jianrong Steve

Wu, Chunlin; Qin, Xurong; Moeljadi, Adhitya Mangala Putra; Hirao, Hajime; Zhou, Jianrong Steve.

Afiliación

Wu C; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, SPMS-CBC-06-06, Singapore, 637371, Singapore.
Qin X; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, SPMS-CBC-06-06, Singapore, 637371, Singapore.
Moeljadi AMP; Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.
Hirao H; Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.
Zhou JS; Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, SPMS-CBC-06-06, Singapore, 637371, Singapore.

Angew Chem Int Ed Engl ; 58(9): 2705-2709, 2019 02 25.

Article en En | MEDLINE | ID: mdl-30648341

ABSTRACT

ABSTRACT

Copper complexes of monodentate phosphoramidites efficiently promote asymmetric arylation of N-azaaryl aldimines with arylboroxines. DFT calculations and experiments support an elementary step of 1,4-insertion in the reaction pathway, a step in which an aryl-copper species adds directly across four atoms of C=N-C=N in the N-azaaryl aldimines.

Palabras clave

1,4-insertion; arylation; asymmetric catalysis; copper catalysis; phosphoramidate

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2019 Tipo del documento: Article País de afiliación: Singapur

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