Galectin-3 Inhibits Cancer Metastasis by Negatively Regulating Integrin ß3 Expression.
Am J Pathol
; 189(4): 900-910, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-30653955
ABSTRACT
Galectin-3 (Gal-3; gene LGALS3) is a member of the ß-galactose-binding lectin family. Previous studies showed that Gal-3 is expressed in several tissues across species and functions as a regulator of cell proliferation, apoptosis, adhesion, and migration, thus affecting many aspects of events, such as angiogenesis and tumorigenesis. Although several reports have suggested that the level of Gal-3 expression correlates positively with tumor progression, herein we show that highly metastatic mouse melanoma B16/BL6 cells express less Gal-3 than B16 cells with a lower metastatic potential. It was found that overexpression of Gal-3 in melanoma cells in fact suppresses metastasis. In contrast, knocking out Gal-3 expression in cancer cells promoted cell aggregation mediated through interactions with platelets and fibrinogen in vitro and increased the number of metastatic foci in vivo. Thus, reduced Gal-3 expression results in the up-regulation of ß3 integrin expression, and this contributes to metastatic potential. These findings indicate that changes of Gal-3 expression in cancer cells during tumor progression influence the characteristics of metastatic cells.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Melanoma Experimental
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Regulación Neoplásica de la Expresión Génica
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Galectina 3
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Integrina beta3
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Neoplasias Pulmonares
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Neovascularización Patológica
Límite:
Animals
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Humans
Idioma:
En
Revista:
Am J Pathol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Japón