Short-term exposure to ambient air pollution and circulating biomarkers of endothelial cell activation: The Framingham Heart Study.
Environ Res
; 171: 36-43, 2019 04.
Article
en En
| MEDLINE
| ID: mdl-30654247
ABSTRACT
BACKGROUND:
Short-term exposure to air pollution has been associated with cardiovascular events, potentially by promoting endothelial cell activation and inflammation. A few large-scale studies have examined the associations and have had mixed results.METHODS:
We included 3820 non-current smoking participants (mean age 56 years, 54% women) from the Framingham Offspring cohort examinations 7 (1998-2001) and 8 (2005-2008), and Third Generation cohort examination 1 (2002-2005), who lived within 50â¯km of a central monitoring station. We calculated the 1- to 7-day moving averages of fine particulate matter (PM2.5), black carbon (BC), sulfate (SO42-), nitrogen oxides (NOx), and ozone before examination visits. We used linear mixed effect models for P-selectin, monocyte chemoattractant protein 1 (MCP-1), intercellular adhesion molecule 1, lipoprotein-associated phospholipase A2 activity and mass, and osteoprotegerin that were measured up to twice, and linear regression models for CD40 ligand and interleukin-18 that were measured once, adjusting for demographics, life style and clinical factors, socioeconomic position, time, and meteorology.RESULTS:
We found negative associations of PM2.5 and BC with P-selectin, of ozone with MCP-1, and of SO42- and NOx with osteoprotegerin. At the 5-day moving average, a 5⯵g/m3 higher PM2.5 was associated with 1.6% (95% CI -â¯2.8, -â¯0.3) lower levels of P-selectin; a 10 ppb higher ozone was associated with 1.7% (95% CI -â¯3.2, -â¯0.1) lower levels of MCP-1; and a 20 ppb higher NOx was associated with 2.0% (95% CI -â¯3.6, -â¯0.4) lower levels of osteoprotegerin.CONCLUSIONS:
We did not find evidence of positive associations between short-term air pollution exposure and endothelial cell activation. On the contrary, short-term exposure to higher levels of ambient pollutants were associated with lower levels of P-selectin, MCP-1, and osteoprotegerin in the Framingham Heart Study.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Biomarcadores
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Células Endoteliales
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Contaminación del Aire
/
Exposición a Riesgos Ambientales
Tipo de estudio:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Environ Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos