Design, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1&#945; pathway.

Wu, Jie; Zhang, Zhi-Hong; Zhang, Lin-Hao; Jin, Xue-Jun; Ma, Juan; Piao, Hu-Ri

Design, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1α pathway.

Wu, Jie; Zhang, Zhi-Hong; Zhang, Lin-Hao; Jin, Xue-Jun; Ma, Juan; Piao, Hu-Ri.

Afiliación

Wu J; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
Zhang ZH; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
Zhang LH; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
Jin XJ; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
Ma J; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China. Electronic address: majuan@ybu.edu.cn.
Piao HR; Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China. Electronic address: piaohr@ybu.edu.cn.

Bioorg Med Chem Lett ; 29(6): 853-858, 2019 03 15.

Article en En | MEDLINE | ID: mdl-30728113

Asunto(s)

Antineoplásicos/farmacología; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Transducción de Señal/efectos de los fármacos; Triterpenos/farmacología; Antineoplásicos/síntesis química; Antineoplásicos/química; Línea Celular Tumoral; Diseño de Fármacos; Humanos; Estructura Molecular; ARN Mensajero/metabolismo; Relación Estructura-Actividad; Triterpenos/síntesis química; Triterpenos/química; Factor A de Crecimiento Endotelial Vascular/genética

Palabras clave

Aminoguanidine; Anticancer activity; Cytotoxicity; HIF-1α inhibitor; Ursolic acid

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triterpenos / Transducción de Señal / Subunidad alfa del Factor 1 Inducible por Hipoxia / Antineoplásicos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google