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Allergen immunotherapy for IgE-mediated food allergy: There is a measure in everything to a proper proportion of therapy.
Pajno, Giovanni Battista; Castagnoli, Riccardo; Muraro, Antonella; Alvaro-Lozano, Montserrat; Akdis, Cezmi A; Akdis, Mubeccel; Arasi, Stefania.
Afiliación
  • Pajno GB; Department of Pediatrics, Allergy Unit, University of Messina, Messina, Italy.
  • Castagnoli R; Pediatric Clinic, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
  • Muraro A; Department of Women and Child Health, Food Allergy Referral Centre Veneto Region, Padua General University Hospital, Padua, Italy.
  • Alvaro-Lozano M; Paediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.
  • Akdis CA; Swiss Institute for Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
  • Akdis M; Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.
  • Arasi S; Swiss Institute for Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Pediatr Allergy Immunol ; 30(4): 415-422, 2019 06.
Article en En | MEDLINE | ID: mdl-30770574
IgE-mediated food allergy (FA) is a potentially life-threatening condition with a negative impact on quality of life and an increasing prevalence in westernized countries in the recent two decades. A strict avoidance of the triggering food(s) represents the current standard approach. However, an elimination diet may be difficult and frustrating, in particular for common foods, (eg, milk, egg, and peanut). Food allergy immunotherapy (FA-AIT) may provide an active treatment that enables to increase the amount of food that the patient can intake without reaction during treatment (ie, desensitization), and reduces the risk of potential life-threatening allergic reaction in the event of accidental ingestion. However, several gaps need still to be filled. A memorable Latin orator stated: "Est modus in rebus" (Horace, Sermones I, 1, 106-07). This sentence remembers that there is a measure in everything to a proper proportion of therapy. The common sense of measure should find application in each stage of treatment. A personalized approaching should consider the specific willing and features of each patient. Efforts are devoted to improve the efficacy, the safety but also the quality of life of patients suffering from FA. In the near future, it will be important to clarify immunologic pathways of FA-AIT, and to identify reliable biomarkers in order to recognize the most suitable candidates to FA-AIT and algorithms for treatments tailored on well-characterized subpopulations of patients.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Alérgenos / Desensibilización Inmunológica / Hipersensibilidad a los Alimentos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Pediatr Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / PEDIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Alérgenos / Desensibilización Inmunológica / Hipersensibilidad a los Alimentos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Pediatr Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / PEDIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Italia