Systemic treatment for metastatic colorectal cancer in the era of precision medicine.

Sandhu, Jaideep; Lavingia, Viraj; Fakih, Marwan

Sandhu, Jaideep; Lavingia, Viraj; Fakih, Marwan.

Afiliación

Sandhu J; Department of Medical Oncology, City of Hope National Medical Center, Duarte, California.
Lavingia V; HCG Cancer Center, Ahmedabad, India.
Fakih M; Medical Oncology and Therapeutics Research, Briskin Center for Clinical Research, GI Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, California.

J Surg Oncol ; 119(5): 564-582, 2019 Apr.

Article en En | MEDLINE | ID: mdl-30802315

ABSTRACT

ABSTRACT

The treatment of metastatic colorectal cancer has evolved over the last two decades with the FDA approval of several cytotoxic, biological, and targeted agents. In this paper, we review the impact of sidedness, RAS, BRAF, HER-2, and other immune biomarkers on metastatic colorectal cancer treatment selection and sequencing in both the palliative and curative intent settings.

Asunto(s)

Neoplasias Colorrectales/tratamiento farmacológico; Neoplasias Colorrectales/patología; Medicina de Precisión; Inhibidores de la Angiogénesis/uso terapéutico; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico; Neoplasias Colorrectales/genética; Receptores ErbB/antagonistas & inhibidores; Humanos; Terapia Molecular Dirigida; Mutación; Terapia Neoadyuvante; Proteínas Proto-Oncogénicas B-raf/antagonistas & inhibidores; Receptor ErbB-2/antagonistas & inhibidores

Palabras clave

biomarkers; chemotherapy; colorectal cancer; immunotherapy; targeted therapy

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Medicina de Precisión Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Surg Oncol Año: 2019 Tipo del documento: Article

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