Inhibition of thymocyte autophagy-associated CD4<sup>+</sup>T thymopoiesis is involved in asthma susceptibility in mice exposed to caffeine prenatally.

Liu, Han-Xiao; Yan, Hui-Yi; Qu, Wen; Wen, Xiao; Hou, Li-Fang; Zhao, Wen-Hao; Ping, Jie

Inhibition of thymocyte autophagy-associated CD4⁺T thymopoiesis is involved in asthma susceptibility in mice exposed to caffeine prenatally.

Liu, Han-Xiao; Yan, Hui-Yi; Qu, Wen; Wen, Xiao; Hou, Li-Fang; Zhao, Wen-Hao; Ping, Jie.

Afiliación

Liu HX; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, 185, East Lake Road, Wuhan, 430071, China.
Yan HY; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, 185, East Lake Road, Wuhan, 430071, China.
Qu W; Wuhan Mental Health Center, Wuhan Hospital for Psychotherapy, Wuhan, 430012, China.
Wen X; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, 185, East Lake Road, Wuhan, 430071, China.
Hou LF; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, 185, East Lake Road, Wuhan, 430071, China.
Zhao WH; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, 185, East Lake Road, Wuhan, 430071, China.
Ping J; Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, 185, East Lake Road, Wuhan, 430071, China.

Arch Toxicol ; 93(5): 1323-1335, 2019 05.

Article en En | MEDLINE | ID: mdl-30805671

Asunto(s)

Asma/etiología; Cafeína/toxicidad; Efectos Tardíos de la Exposición Prenatal/fisiopatología; Timocitos/efectos de los fármacos; Animales; Autofagia/efectos de los fármacos; Linfocitos T CD4-Positivos/metabolismo; Cafeína/administración & dosificación; Estimulantes del Sistema Nervioso Central/administración & dosificación; Estimulantes del Sistema Nervioso Central/toxicidad; Femenino; Masculino; Ratones; Ratones Endogámicos BALB C; Embarazo; Timocitos/citología

Palabras clave

Asthma; Autophagy; CD4+T deviation; Immunotoxicity; Prenatal caffeine exposure; Thymocyte

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Asma / Cafeína / Timocitos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Pregnancy Idioma: En Revista: Arch Toxicol Año: 2019 Tipo del documento: Article País de afiliación: China

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