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OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug.
Banerjee, Shuvojit; Gusho, Elona; Gaughan, Christina; Dong, Beihua; Gu, Xiaorong; Holvey-Bates, Elise; Talukdar, Manisha; Li, Yize; Weiss, Susan R; Sicheri, Frank; Saunthararajah, Yogen; Stark, George R; Silverman, Robert H.
Afiliación
  • Banerjee S; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
  • Gusho E; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
  • Gaughan C; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
  • Dong B; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
  • Gu X; Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195.
  • Holvey-Bates E; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
  • Talukdar M; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Li Y; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
  • Weiss SR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
  • Sicheri F; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
  • Saunthararajah Y; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Stark GR; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
  • Silverman RH; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Proc Natl Acad Sci U S A ; 116(11): 5071-5076, 2019 03 12.
Article en En | MEDLINE | ID: mdl-30814222
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Azacitidina / 2',5'-Oligoadenilato Sintetasa / Endorribonucleasas / Desmetilación del ADN / Inmunidad Innata Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Azacitidina / 2',5'-Oligoadenilato Sintetasa / Endorribonucleasas / Desmetilación del ADN / Inmunidad Innata Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article