Vaccinia Virus BBK E3 Ligase Adaptor A55 Targets Importin-Dependent NF-&#954;B Activation and Inhibits CD8<sup>+</sup> T-Cell Memory.

Pallett, Mitchell A; Ren, Hongwei; Zhang, Rui-Yao; Scutts, Simon R; Gonzalez, Laura; Zhu, Zihan; Maluquer de Motes, Carlos; Smith, Geoffrey L

Vaccinia Virus BBK E3 Ligase Adaptor A55 Targets Importin-Dependent NF-κB Activation and Inhibits CD8⁺ T-Cell Memory.

Pallett, Mitchell A; Ren, Hongwei; Zhang, Rui-Yao; Scutts, Simon R; Gonzalez, Laura; Zhu, Zihan; Maluquer de Motes, Carlos; Smith, Geoffrey L.

Afiliación

Pallett MA; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Ren H; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Zhang RY; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Scutts SR; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Gonzalez L; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Zhu Z; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Maluquer de Motes C; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Smith GL; Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom gls37@cam.ac.uk.

J Virol ; 93(10)2019 05 15.

Article en En | MEDLINE | ID: mdl-30814284

Asunto(s)

Evasión Inmune/fisiología; FN-kappa B/antagonistas & inhibidores; Virus Vaccinia/metabolismo; Animales; Dominio BTB-POZ; Línea Celular; Proteínas Cullin/metabolismo; Femenino; Células HEK293; Humanos; Inmunidad Innata; Carioferinas/metabolismo; Secuencia Kelch/fisiología; Ratones; Ratones Endogámicos C57BL; FN-kappa B/metabolismo; Poxviridae/metabolismo; Transducción de Señal; Linfocitos T/metabolismo; Ubiquitina-Proteína Ligasas/metabolismo; Vaccinia/virología; Proteínas Virales/metabolismo; Virulencia; Replicación Viral/fisiología; alfa Carioferinas/metabolismo

Palabras clave

BTB-Kelch; E3 ligase; NF-κB; cullin-3; importins; protein A55; vaccinia virus

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Virus Vaccinia / FN-kappa B / Evasión Inmune Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: J Virol Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido

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