3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation.

Zhai, Min'an; Liu, Shiyuan; Gao, Meiqi; Wang, Long; Sun, Jun; Du, Jianan; Guan, Qi; Bao, Kai; Zuo, Daiying; Wu, Yingliang; Zhang, Weige

Zhai, Min'an; Liu, Shiyuan; Gao, Meiqi; Wang, Long; Sun, Jun; Du, Jianan; Guan, Qi; Bao, Kai; Zuo, Daiying; Wu, Yingliang; Zhang, Weige.

Afiliación

Zhai M; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Liu S; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Gao M; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Wang L; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Sun J; Clinical Pharmacology Laboratory, Henan Province People's Hospital, 7 Weiwu Road, Jinshui District, Zhengzhou, 450003, China.
Du J; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Guan Q; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address: guanqi@syphu.edu.cn.
Bao K; Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Zuo D; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China.
Wu Y; Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address: yingliang_1016@163.com.
Zhang W; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, China. Electronic address: zhangweige2000@sina.com.

Eur J Med Chem ; 168: 426-435, 2019 Apr 15.

Article en En | MEDLINE | ID: mdl-30831410

Asunto(s)

Antineoplásicos/farmacología; Diseño de Fármacos; Pirazoles/farmacología; Piridinas/farmacología; Tubulina (Proteína)/metabolismo; Antineoplásicos/síntesis química; Antineoplásicos/química; Puntos de Control del Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Teoría Funcional de la Densidad; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Modelos Moleculares; Estructura Molecular; Polimerizacion/efectos de los fármacos; Pirazoles/síntesis química; Pirazoles/química; Piridinas/síntesis química; Piridinas/química; Relación Estructura-Actividad

Palabras clave

Colchicine site; Conformational analysis; Pyrazolo[3,4-b]pyridine; Ring tethering

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Piridinas / Tubulina (Proteína) / Diseño de Fármacos / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: China

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