Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling.

Pollyea, Daniel A; Harris, Chelsea; Rabe, Jennifer L; Hedin, Brenna R; De Arras, Lesly; Katz, Sigrid; Wheeler, Emily; Bejar, Rafael; Walter, Matthew J; Jordan, Craig T; Pietras, Eric M; Alper, Scott

Pollyea, Daniel A; Harris, Chelsea; Rabe, Jennifer L; Hedin, Brenna R; De Arras, Lesly; Katz, Sigrid; Wheeler, Emily; Bejar, Rafael; Walter, Matthew J; Jordan, Craig T; Pietras, Eric M; Alper, Scott.

Afiliación

Pollyea DA; Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.
Harris C; Department of Biomedical Research, National Jewish Health, Denver, CO.
Rabe JL; Center for Genes, Environment and Health, National Jewish Health, Denver, CO.
Hedin BR; Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.
De Arras L; Department of Biomedical Research, National Jewish Health, Denver, CO.
Katz S; Center for Genes, Environment and Health, National Jewish Health, Denver, CO.
Wheeler E; Center for Genes, Environment and Health, National Jewish Health, Denver, CO.
Bejar R; Division of Hematology and Oncology, University of California, San Diego, La Jolla, CA.
Walter MJ; Division of Hematology and Oncology, University of California, San Diego, La Jolla, CA.
Jordan CT; Division of Hematology and Oncology, University of California, San Diego, La Jolla, CA.
Pietras EM; Division of Oncology, Department of Medicine, Washington University, St. Louis, MO.
Alper S; Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.

Haematologica ; 104(9): e388-e392, 2019 09.

Article en En | MEDLINE | ID: mdl-30846499

Asunto(s)

Inmunidad Innata; Síndromes Mielodisplásicos/genética; Fosfoproteínas/genética; Factores de Empalme de ARN/genética; Factores de Empalme Serina-Arginina/genética; Empalmosomas/genética; Factor de Empalme U2AF/genética; Animales; Citocinas/metabolismo; Humanos; Inflamación; Células K562; Lipopolisacáridos; Ratones; Mutación; Subunidad p50 de NF-kappa B/metabolismo; Fenotipo; Células RAW 264.7; Empalme del ARN

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfoproteínas / Síndromes Mielodisplásicos / Empalmosomas / Factores de Empalme Serina-Arginina / Factores de Empalme de ARN / Factor de Empalme U2AF / Inmunidad Innata Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Haematologica Año: 2019 Tipo del documento: Article País de afiliación: Colombia

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