Anti-diabetic potential of Pueraria lobata root extract through promoting insulin signaling by PTP1B inhibition.

Sun, Ran; Deng, Xinxian; Zhang, Dongdong; Xie, Fangzhou; Wang, Di; Wang, Juntao; Tavallaie, Mojdeh S; Jiang, Faqin; Fu, Lei

Sun, Ran; Deng, Xinxian; Zhang, Dongdong; Xie, Fangzhou; Wang, Di; Wang, Juntao; Tavallaie, Mojdeh S; Jiang, Faqin; Fu, Lei.

Afiliación

Sun R; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), 800 Dongchuan Road, Shanghai 200240, China.
Deng X; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), 800 Dongchuan Road, Shanghai 200240, China.
Zhang D; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), 800 Dongchuan Road, Shanghai 200240, China.
Xie F; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), 800 Dongchuan Road, Shanghai 200240, China.
Wang D; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), 800 Dongchuan Road, Shanghai 200240, China.
Wang J; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), 800 Dongchuan Road, Shanghai 200240, China.
Tavallaie MS; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), 800 Dongchuan Road, Shanghai 200240, China.
Jiang F; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), 800 Dongchuan Road, Shanghai 200240, China. Electronic address: jfq2008@sjtu.edu.cn.
Fu L; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University (SJTU), 800 Dongchuan Road, Shanghai 200240, China. Electronic address: leifu@sjtu.edu.cn.

Bioorg Chem ; 87: 12-15, 2019 06.

Article en En | MEDLINE | ID: mdl-30852232

Asunto(s)

Antineoplásicos Fitogénicos/farmacología; Diabetes Mellitus Experimental/tratamiento farmacológico; Hipoglucemiantes/farmacología; Insulina/metabolismo; Extractos Vegetales/farmacología; Proteína Tirosina Fosfatasa no Receptora Tipo 1/antagonistas & inhibidores; Pueraria/química; Animales; Antineoplásicos Fitogénicos/química; Antineoplásicos Fitogénicos/aislamiento & purificación; Proliferación Celular/efectos de los fármacos; Diabetes Mellitus Experimental/metabolismo; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Células Hep G2; Humanos; Hipoglucemiantes/química; Hipoglucemiantes/aislamiento & purificación; Masculino; Ratones; Ratones Endogámicos C57BL; Simulación del Acoplamiento Molecular; Estructura Molecular; Extractos Vegetales/química; Extractos Vegetales/aislamiento & purificación; Raíces de Plantas/química; Proteína Tirosina Fosfatasa no Receptora Tipo 1/metabolismo; Transducción de Señal/efectos de los fármacos; Relación Estructura-Actividad; Células Tumorales Cultivadas

Palabras clave

Anti-diabetic activities; PTP1B; Pueraria lobata; T2DM

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Extractos Vegetales / Pueraria / Diabetes Mellitus Experimental / Proteína Tirosina Fosfatasa no Receptora Tipo 1 / Hipoglucemiantes / Insulina / Antineoplásicos Fitogénicos Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: China

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