A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers.

Rao, Suman; Du, Guangyan; Hafner, Marc; Subramanian, Kartik; Sorger, Peter K; Gray, Nathanael S

Rao, Suman; Du, Guangyan; Hafner, Marc; Subramanian, Kartik; Sorger, Peter K; Gray, Nathanael S.

Afiliación

Rao S; Laboratory of Systems Pharmacology, Boston, Massachusetts 02115; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
Du G; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
Hafner M; Laboratory of Systems Pharmacology, Boston, Massachusetts 02115.
Subramanian K; Laboratory of Systems Pharmacology, Boston, Massachusetts 02115.
Sorger PK; Laboratory of Systems Pharmacology, Boston, Massachusetts 02115.
Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115. Electronic address: Nathanael_Gray@dfci.harvard.edu.

J Biol Chem ; 294(21): 8664-8673, 2019 05 24.

Article en En | MEDLINE | ID: mdl-30858179

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas/enzimología; Neoplasias Pulmonares/epidemiología; MAP Quinasa Quinasa 1/antagonistas & inhibidores; MAP Quinasa Quinasa 2/antagonistas & inhibidores; Inhibidores de Proteínas Quinasas/farmacología; Proteínas Proto-Oncogénicas p21(ras)/antagonistas & inhibidores; Receptor de Insulina/antagonistas & inhibidores; Receptores de Somatomedina/antagonistas & inhibidores; Transducción de Señal/efectos de los fármacos; Antígenos CD/metabolismo; Carcinoma de Pulmón de Células no Pequeñas/patología; Células HCT116; Humanos; MAP Quinasa Quinasa 1/metabolismo; MAP Quinasa Quinasa 2/metabolismo; Inhibidores de Proteínas Quinasas/química; Proteínas Proto-Oncogénicas p21(ras)/metabolismo; Receptor IGF Tipo 1; Receptor de Insulina/metabolismo; Receptores de Somatomedina/metabolismo

Palabras clave

cancer biology; cancer therapy; cell signaling; chemical biology; chemical probe; drug discovery; kinase signaling; multi-targeting; polypharmacology; receptor tyrosine kinase; small molecule

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptor de Insulina / Transducción de Señal / Proteínas Proto-Oncogénicas p21(ras) / Receptores de Somatomedina / Carcinoma de Pulmón de Células no Pequeñas / MAP Quinasa Quinasa 1 / MAP Quinasa Quinasa 2 / Inhibidores de Proteínas Quinasas / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

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