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A Mild, DNA-Compatible Nitro Reduction Using B2(OH)4.
Du, Huang-Chi; Simmons, Nicholas; Faver, John C; Yu, Zhifeng; Palaniappan, Murugesan; Riehle, Kevin; Matzuk, Martin M.
Afiliación
  • Du HC; Center for Drug Discovery , Baylor College of Medicine , Houston , Texas 77030 , United States.
  • Simmons N; Center for Drug Discovery , Baylor College of Medicine , Houston , Texas 77030 , United States.
  • Faver JC; Center for Drug Discovery , Baylor College of Medicine , Houston , Texas 77030 , United States.
  • Yu Z; Center for Drug Discovery , Baylor College of Medicine , Houston , Texas 77030 , United States.
  • Palaniappan M; Center for Drug Discovery , Baylor College of Medicine , Houston , Texas 77030 , United States.
  • Riehle K; Center for Drug Discovery , Baylor College of Medicine , Houston , Texas 77030 , United States.
  • Matzuk MM; Center for Drug Discovery , Baylor College of Medicine , Houston , Texas 77030 , United States.
Org Lett ; 21(7): 2194-2199, 2019 04 05.
Article en En | MEDLINE | ID: mdl-30860855
A hypodiboric acid system for the reduction of nitro groups on DNA-chemical conjugates has been developed. This transformation provided good to excellent yields of the reduced amine product for a variety of functionalized aromatic, heterocyclic, and aliphatic nitro compounds. DNA tolerance to reaction conditions, extension to decigram scale reductions, successful use in a DNA-encoded chemical library synthesis, and subsequent target selection are also described.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compuestos de Boro / ADN / Aminas / Nitrocompuestos Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Compuestos de Boro / ADN / Aminas / Nitrocompuestos Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos