A reevaluation of the spleen tyrosine kinase (SYK) activation mechanism.

Mansueto, My S; Reens, Abigail; Rakhilina, Larissa; Chi, An; Pan, Bo-Sheng; Miller, J Richard

Mansueto, My S; Reens, Abigail; Rakhilina, Larissa; Chi, An; Pan, Bo-Sheng; Miller, J Richard.

Afiliación

Mansueto MS; From the Departments of Pharmacology and.
Reens A; From the Departments of Pharmacology and.
Rakhilina L; From the Departments of Pharmacology and.
Chi A; Chemical Biology, Merck & Co., Inc., Boston, Massachusetts 02115.
Pan BS; From the Departments of Pharmacology and.
Miller JR; From the Departments of Pharmacology and james.miller2@merck.com.

J Biol Chem ; 294(19): 7658-7668, 2019 05 10.

Article en En | MEDLINE | ID: mdl-30923129

Asunto(s)

Modelos Químicos; Quinasa Syk/química; Secuencias de Aminoácidos; Activación Enzimática; Humanos; Fosforilación; Proto-Oncogenes Mas; Quinasa Syk/metabolismo; Dominios Homologos src; Familia-src Quinasas/química; Familia-src Quinasas/metabolismo

Palabras clave

ITAM (immune-receptor tyrosine activation motif); autophosphorylation; cell signaling; conformational change; enzyme activation; enzyme kinetics; immunity; non-receptor tyrosine kinase (nRTK); phosphorylation; spleen tyrosine kinase (SYK); tonic signalling

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinasa Syk / Modelos Químicos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

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