Lessons from Worm Dendritic Patterning.
Annu Rev Neurosci
; 42: 365-383, 2019 07 08.
Article
en En
| MEDLINE
| ID: mdl-30939099
ABSTRACT
The structural and functional properties of neurons have intrigued scientists since the pioneering work of Santiago Ramón y Cajal. Since then, emerging cutting-edge technologies, including light and electron microscopy, electrophysiology, biochemistry, optogenetics, and molecular biology, have dramatically increased our understanding of dendritic properties. This advancement was also facilitated by the establishment of different animal model organisms, from flies to mammals. Here we describe the emerging model system of a Caenorhabditis elegans polymodal neuron named PVD, whose dendritic tree follows a stereotypical structure characterized by repeating candelabra-like structural units. In the past decade, progress has been made in understanding PVD's functions, morphogenesis, regeneration, and aging, yet many questions still remain.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Regeneración
/
Envejecimiento
/
Dendritas
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Neurosci
Año:
2019
Tipo del documento:
Article