Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway.

Zakaria, Zainul Amiruddin; Abdul Rahim, Mohammad Hafiz; Mohd Sani, Mohd Hijaz; Omar, Maizatul Hasyima; Ching, Siew Mooi; Abdul Kadir, Arifah; Ahmed, Qamar Uddin

Zakaria, Zainul Amiruddin; Abdul Rahim, Mohammad Hafiz; Mohd Sani, Mohd Hijaz; Omar, Maizatul Hasyima; Ching, Siew Mooi; Abdul Kadir, Arifah; Ahmed, Qamar Uddin.

Afiliación

Zakaria ZA; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. drzazakaria@gmail.com.
Abdul Rahim MH; Integrative Pharmacogenomics Institute (iPROMISE), Level 7, FF3, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor, Malaysia. drzazakaria@gmail.com.
Mohd Sani MH; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Omar MH; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Ching SM; Phytochemistry Unit, Herbal Medicine Research Centre, Institute for Medical Research, 50588, Jalan Pahang, Kuala Lumpur, Malaysia.
Abdul Kadir A; Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Ahmed QU; Department of Veterinary Pre-Clinical Science, Faculty of Veterinary Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

BMC Complement Altern Med ; 19(1): 79, 2019 Apr 02.

Article en En | MEDLINE | ID: mdl-30940120

Asunto(s)

Acanthaceae/química; Analgésicos/farmacología; GMP Cíclico/metabolismo; Óxido Nítrico/metabolismo; Extractos Vegetales/farmacología; Receptores Opioides/efectos de los fármacos; Alcanos; Analgésicos/química; Animales; Masculino; Ratones; Ratones Endogámicos ICR; Extractos Vegetales/química; Hojas de la Planta/química; Receptores Opioides/metabolismo; Transducción de Señal/efectos de los fármacos

Palabras clave

Antinociceptive; Clinacanthus nutans; Acanthaceae; Mechanisms of action; NO-mediated/cGMP-independent pathway; phenolic compounds; Opioid receptors

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Extractos Vegetales / GMP Cíclico / Receptores Opioides / Acanthaceae / Analgésicos / Óxido Nítrico Límite: Animals Idioma: En Revista: BMC Complement Altern Med Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article País de afiliación: Malasia

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