RNA-Guided Adenosine Deaminases: Advances and Challenges for Therapeutic RNA Editing.
Biochemistry
; 58(15): 1947-1957, 2019 04 16.
Article
en En
| MEDLINE
| ID: mdl-30943016
ABSTRACT
Targeted transcriptome engineering, in contrast to genome engineering, offers a complementary and potentially tunable and reversible strategy for cellular engineering. In this regard, adenosine to inosine (A-to-I) RNA base editing was recently engineered to make programmable base conversions on target RNAs. Similar to the DNA base editing technology, A-to-I RNA editing may offer an attractive alternative in a therapeutic setting, especially for the correction of point mutations. This Perspective introduces five currently characterized RNA editing systems and serves as a reader's guide for implementing an appropriate RNA editing strategy for applications in research or therapeutics.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ARN
/
Adenosina
/
Adenosina Desaminasa
/
ARN Guía de Kinetoplastida
/
Edición de ARN
/
Inosina
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochemistry
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos