The cyanobacterial neurotoxin ß-N-methylamino-l-alanine prevents addition of heparan sulfate to glypican-1 and increases processing of amyloid precursor protein in dividing neuronal cells.

Cheng, Fang; Fransson, Lars-Åke; Mani, Katrin

Cheng, Fang; Fransson, Lars-Åke; Mani, Katrin.

Afiliación

Cheng F; Department of Experimental Medical Science, Division of Neuroscience, Glycobiology Group, Lund University, Biomedical Center A13, SE-221 84, Lund, Sweden.
Fransson LÅ; Department of Experimental Medical Science, Division of Neuroscience, Glycobiology Group, Lund University, Biomedical Center A13, SE-221 84, Lund, Sweden.
Mani K; Department of Experimental Medical Science, Division of Neuroscience, Glycobiology Group, Lund University, Biomedical Center A13, SE-221 84, Lund, Sweden. Electronic address: katrin.mani@med.lu.se.

Exp Cell Res ; 379(2): 172-181, 2019 06 15.

Article en En | MEDLINE | ID: mdl-30953622

Asunto(s)

Aminoácidos Diaminos/farmacología; Precursor de Proteína beta-Amiloide/metabolismo; Endosomas/efectos de los fármacos; Glipicanos/metabolismo; Neuronas/efectos de los fármacos; Péptidos beta-Amiloides/efectos de los fármacos; Péptidos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/efectos de los fármacos; Animales; Proteínas Portadoras/metabolismo; Toxinas de Cianobacterias; Endosomas/metabolismo; Heparitina Sulfato/metabolismo; Humanos; Ratones; Neuronas/metabolismo; Proteoglicanos/metabolismo

Palabras clave

Alzheimer's disease; Amyloid precursor protein; Glypican-1; Heparan sulfate; Neuronal cells; Neurotoxin

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Endosomas / Precursor de Proteína beta-Amiloide / Glipicanos / Aminoácidos Diaminos / Neuronas Límite: Animals / Humans Idioma: En Revista: Exp Cell Res Año: 2019 Tipo del documento: Article País de afiliación: Suecia

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