H<sub>2</sub>O<sub>2</sub> induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism.

Chen, Mei-Kuang; Du, Yi; Sun, Linlin; Hsu, Jennifer L; Wang, Yu-Han; Gao, Yuan; Huang, Jiaxing; Hung, Mien-Chie

H₂O₂ induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism.

Chen, Mei-Kuang; Du, Yi; Sun, Linlin; Hsu, Jennifer L; Wang, Yu-Han; Gao, Yuan; Huang, Jiaxing; Hung, Mien-Chie.

Afiliación

Chen MK; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.
Du Y; Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.
Sun L; Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
Hsu JL; Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.
Wang YH; Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 402, Taiwan.
Gao Y; Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Huang J; Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Hung MC; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030; Gr

J Biol Chem ; 294(21): 8516-8528, 2019 05 24.

Article en En | MEDLINE | ID: mdl-30962283

Asunto(s)

Neoplasias de la Mama/enzimología; Membrana Celular/enzimología; Núcleo Celular/enzimología; Peróxido de Hidrógeno/farmacología; Proteínas Proto-Oncogénicas c-met/metabolismo; Transducción de Señal/efectos de los fármacos; Transporte Activo de Núcleo Celular/efectos de los fármacos; Neoplasias de la Mama/genética; Neoplasias de la Mama/patología; Línea Celular Tumoral; Membrana Celular/genética; Membrana Celular/patología; Núcleo Celular/genética; Núcleo Celular/patología; Proteína Coatómero/genética; Proteína Coatómero/metabolismo; Daño del ADN; Reparación del ADN; Femenino; Humanos; Proteínas Proto-Oncogénicas c-met/genética; Canales de Translocación SEC/genética; Canales de Translocación SEC/metabolismo

Palabras clave

breast cancer; c-MET; hepatocyte growth factor receptor (HGFR); hydrogen peroxide; nuclear transport; nucleus; reactive oxygen species (ROS); receptor tyrosine kinase; vesicle trafficking

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Transducción de Señal / Membrana Celular / Núcleo Celular / Proteínas Proto-Oncogénicas c-met / Peróxido de Hidrógeno Límite: Female / Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google