Quality and quantity control of gene expression by nonsense-mediated mRNA decay.
Nat Rev Mol Cell Biol
; 20(7): 406-420, 2019 07.
Article
en En
| MEDLINE
| ID: mdl-30992545
ABSTRACT
Nonsense-mediated mRNA decay (NMD) is one of the best characterized and most evolutionarily conserved cellular quality control mechanisms. Although NMD was first found to target one-third of mutated, disease-causing mRNAs, it is now known to also target ~10% of unmutated mammalian mRNAs to facilitate appropriate cellular responses - adaptation, differentiation or death - to environmental changes. Mutations in NMD genes in humans are associated with intellectual disability and cancer. In this Review, we discuss how NMD serves multiple purposes in human cells by degrading both mutated mRNAs to protect the integrity of the transcriptome and normal mRNAs to control the quantities of unmutated transcripts.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ARN Mensajero
/
ARN Neoplásico
/
Regulación Neoplásica de la Expresión Génica
/
Degradación de ARNm Mediada por Codón sin Sentido
/
Transcriptoma
/
Discapacidad Intelectual
/
Mutación
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Mol Cell Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos