Discovery of Small-Molecule Inhibitors Targeting the E3 Ubiquitin Ligase Activity of the Herpes Simplex Virus 1 ICP0 Protein Using an <i>In Vitro</i> High-Throughput Screening Assay.

Deschamps, Thibaut; Waisner, Hope; Dogrammatzis, Christos; Roy, Anuradha; Chacko, Shibin; Perera, Chamani; Prisinzano, Thomas E; Kalamvoki, Maria

Discovery of Small-Molecule Inhibitors Targeting the E3 Ubiquitin Ligase Activity of the Herpes Simplex Virus 1 ICP0 Protein Using an In Vitro High-Throughput Screening Assay.

Deschamps, Thibaut; Waisner, Hope; Dogrammatzis, Christos; Roy, Anuradha; Chacko, Shibin; Perera, Chamani; Prisinzano, Thomas E; Kalamvoki, Maria.

Afiliación

Deschamps T; Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Waisner H; Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Dogrammatzis C; Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Roy A; Infectious Disease Assay Development Core, University of Kansas, Lawrence, Kansas, USA.
Chacko S; Synthetic Chemical Biology Core Facility, University of Kansas, Lawrence, Kansas, USA.
Perera C; Synthetic Chemical Biology Core Facility, University of Kansas, Lawrence, Kansas, USA.
Prisinzano TE; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas, USA.
Kalamvoki M; Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA mkalamvoki@kumc.edu.

J Virol ; 93(13)2019 07 01.

Article en En | MEDLINE | ID: mdl-30996104

Asunto(s)

Herpesvirus Humano 1/efectos de los fármacos; Herpesvirus Humano 1/metabolismo; Ensayos Analíticos de Alto Rendimiento; Proteínas Inmediatas-Precoces/efectos de los fármacos; Proteínas Inmediatas-Precoces/metabolismo; Ubiquitina-Proteína Ligasas/efectos de los fármacos; Línea Celular; Replicación del ADN; Regulación Viral de la Expresión Génica; Herpesvirus Humano 1/genética; Interacciones Huésped-Patógeno; Humanos; Proteínas Inmediatas-Precoces/genética; Ubiquitina-Proteína Ligasas/genética; Ubiquitina-Proteína Ligasas/metabolismo; Proteínas Virales; Replicación Viral/efectos de los fármacos

Palabras clave

E3 ubiquitin ligase; HSV; ICP0; high-throughput screening assay; small-molecule inhibitors

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Inmediatas-Precoces / Herpesvirus Humano 1 / Ubiquitina-Proteína Ligasas / Ensayos Analíticos de Alto Rendimiento Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: J Virol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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