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Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics.
Zhang, Ruohan; Ou, Minglin; Zhang, Yue; Yan, Qiang; Chen, Huaizhou; Lai, Liusheng; Li, Ying; Xu, Feilong; Tang, Donge; Sun, Xuyong; Dong, Jianhui; Dai, Yong; Sui, Weiguo.
Afiliación
  • Zhang R; Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department of Guilin 924st Hospital, Guilin, Guangxi 541002, P.R. China.
  • Ou M; Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department of Guilin 924st Hospital, Guilin, Guangxi 541002, P.R. China.
  • Zhang Y; Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department of Guilin 924st Hospital, Guilin, Guangxi 541002, P.R. China.
  • Yan Q; Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department of Guilin 924st Hospital, Guilin, Guangxi 541002, P.R. China.
  • Chen H; Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department of Guilin 924st Hospital, Guilin, Guangxi 541002, P.R. China.
  • Lai L; Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department of Guilin 924st Hospital, Guilin, Guangxi 541002, P.R. China.
  • Li Y; Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department of Guilin 924st Hospital, Guilin, Guangxi 541002, P.R. China.
  • Xu F; Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department of Guilin 924st Hospital, Guilin, Guangxi 541002, P.R. China.
  • Tang D; Clinical Medical Research Center, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, P.R. China.
  • Sun X; Guangxi Key Laboratory for Transplantation Medicine Guangxi, Institute of Transplant Medicine, Department of Organ Transplantation in Guangzhou Military Region, 923st Hospital, Nannning 530021, P.R. China.
  • Dong J; Guangxi Key Laboratory for Transplantation Medicine Guangxi, Institute of Transplant Medicine, Department of Organ Transplantation in Guangzhou Military Region, 923st Hospital, Nannning 530021, P.R. China.
  • Dai Y; Clinical Medical Research Center, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, P.R. China.
  • Sui W; Guangxi Key Laboratory of Metabolic Diseases Research, Nephrology Department of Guilin 924st Hospital, Guilin, Guangxi 541002, P.R. China.
Oncotarget ; 10(26): 2508-2514, 2019 Apr 02.
Article en En | MEDLINE | ID: mdl-31069013
ABSTRACT
Liver cancer is the second leading cause of cancer mortality worldwide. Safer and more effective diagnostic methods for liver cancer are desirable, and biomarkers represent a potentially alternative method for diagnosis. The present study was designed to identify liver cancer biomarkers. We quantified the changes in serum protein levels between liver transplantation and healthy (control) females using isobaric tags for relative and absolute quantitation (iTRAQ) as well as proteomic analysis. A total of 1399 proteins were identified; of these, three proteins showed significantly different concentrations between the before transplantation group and the control group. These proteins may thus be relevant to liver cancer and constitute potential liver cancer biomarkers.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Oncotarget Año: 2019 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Oncotarget Año: 2019 Tipo del documento: Article