A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle.

Plaszczyca, Anna; Scaturro, Pietro; Neufeldt, Christopher John; Cortese, Mirko; Cerikan, Berati; Ferla, Salvatore; Brancale, Andrea; Pichlmair, Andreas; Bartenschlager, Ralf

Plaszczyca, Anna; Scaturro, Pietro; Neufeldt, Christopher John; Cortese, Mirko; Cerikan, Berati; Ferla, Salvatore; Brancale, Andrea; Pichlmair, Andreas; Bartenschlager, Ralf.

Afiliación

Plaszczyca A; Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany.
Scaturro P; Max-Planck Institute of Biochemistry, Innate Immunity Laboratory, Martinsried, Germany.
Neufeldt CJ; School of Medicine, Institute of Virology, Technical University of Munich, Munich, Germany.
Cortese M; Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany.
Cerikan B; Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany.
Ferla S; Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany.
Brancale A; School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom.
Pichlmair A; School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom.
Bartenschlager R; Max-Planck Institute of Biochemistry, Innate Immunity Laboratory, Martinsried, Germany.

PLoS Pathog ; 15(5): e1007736, 2019 05.

Article en En | MEDLINE | ID: mdl-31071189

Asunto(s)

Carcinoma Hepatocelular/virología; Dengue/virología; Neoplasias Hepáticas/virología; Biogénesis de Organelos; Proteínas no Estructurales Virales/metabolismo; Replicación Viral; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patología; Dengue/metabolismo; Dengue/patología; Virus del Dengue/fisiología; Humanos; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patología; Unión Proteica; Conformación Proteica; Mapas de Interacción de Proteínas; Células Tumorales Cultivadas; Proteínas no Estructurales Virales/química

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Replicación Viral / Biogénesis de Organelos / Proteínas no Estructurales Virales / Carcinoma Hepatocelular / Dengue / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: PLoS Pathog Año: 2019 Tipo del documento: Article País de afiliación: Alemania

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google