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COMT val158met is not associated with Aß-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults.
Porter, Tenielle; Burnham, Samantha C; Milicic, Lidija; Savage, Greg; Maruff, Paul; Sohrabi, Hamid R; Peretti, Madeline; Lim, Yen Ying; Weinborn, Michael; Ames, David; Masters, Colin L; Martins, Ralph N; Rainey-Smith, Stephanie; Rowe, Christopher C; Salvado, Olivier; Groth, David; Verdile, Giuseppe; Villemagne, Victor L; Laws, Simon M.
Afiliación
  • Porter T; Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australia.
  • Burnham SC; Cooperative Research Centre for Mental Health, Australia.
  • Milicic L; CSIRO Health and Biosecurity, Parkville 3052, Victoria, Australia.
  • Savage G; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australia.
  • Maruff P; Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australia.
  • Sohrabi HR; Cooperative Research Centre for Mental Health, Australia.
  • Peretti M; ARC Centre of Excellence in Cognition and its Disorders, Department of Psychology, Macquarie University, North Ryde 2113, NSW, Australia.
  • Lim YY; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville 3052, Victoria, Australia.
  • Weinborn M; CogState Ltd., Melbourne 3000, Victoria, Australia.
  • Ames D; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australia.
  • Masters CL; Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australia.
  • Martins RN; Cooperative Research Centre for Mental Health, Australia.
  • Rainey-Smith S; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville 3052, Victoria, Australia.
  • Rowe CC; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australia.
  • Salvado O; School of Psychology, University of Western Australia, Crawley 6009, Western Australia, Australia.
  • Groth D; Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew 3101, Victoria, Australia.
  • Verdile G; National Ageing Research Institute, Parkville 3052, Victoria, Australia.
  • Villemagne VL; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville 3052, Victoria, Australia.
  • Laws SM; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup 6027, Western Australia, Australia.
IBRO Rep ; 6: 147-152, 2019 Jun.
Article en En | MEDLINE | ID: mdl-31080907
The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect of neocortical Aß-amyloid (Aß) accumulation and carriage of the apolipoprotein E (APOE) ε4 allele on cognition in preclinical Alzheimer's disease (AD). In 598 cognitively normal older adults with known neocortical Aß levels, linear mixed modelling revealed no significant independent or interactional associations between COMT Val158Met and cognitive decline. These findings do not support previous associations between COMT Val158Met and cognitive performance and suggest this variant does not influence Aß-amyloid or APOE ε4 driven cognitive decline in a well characterised cohort of cognitively normal older adults.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: IBRO Rep Año: 2019 Tipo del documento: Article País de afiliación: Australia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: IBRO Rep Año: 2019 Tipo del documento: Article País de afiliación: Australia