Flick of a switch: regulatory mechanisms allowing Listeria monocytogenes to transition from a saprophyte to a killer.
Microbiology (Reading)
; 165(8): 819-833, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-31107205
ABSTRACT
In contrast to obligate intracellular pathogens that can remain in relatively stable host-associated environments, the soil-living bacterial pathogen Listeria monocytogenes has to sense and respond to physical and chemical cues in a variety of quite different niches. In particular, the bacterium has to survive the dramatic transition from its saprophytic existence to life within the host where nutritional stress, increased temperature, acidity, osmotic stress and the host defences present a new and challenging landscape. This review focuses on the σB and PrfA regulatory systems used by L. monocytogenes to sense the changing environment and implement survival mechanisms that help to overcome the disparate conditions within the host, but also to switch from a harmless saprophyte to an impressively effective pathogen.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor sigma
/
Proteínas Bacterianas
/
Virulencia
/
Factores de Terminación de Péptidos
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Factores de Virulencia
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Listeria monocytogenes
Idioma:
En
Revista:
Microbiology (Reading)
Asunto de la revista:
MICROBIOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Suecia