Detection of myocarditis using T1 and ECV mapping is not improved by early compared to late post-contrast imaging.
Clin Physiol Funct Imaging
; 39(6): 384-392, 2019 Nov.
Article
en En
| MEDLINE
| ID: mdl-31132211
ABSTRACT
BACKGROUND:
Cardiovascular magnetic resonance (CMR) of myocarditis may include early gadolinium enhancement (EGE) and global relative enhancement (GRE) by T1 -weighted images acquired before and early after contrast administration. However, the importance of timing for post-contrast imaging has not been evaluated using T1 mapping. We aimed to improve the understanding of the contrast mechanisms by evaluating whether early or late post-contrast T1 mapping was better at detecting myocarditis.METHODS:
Controls and patients referred to evaluate myocarditis underwent 1·5T CMR. T1 mapping was performed before, and 3 min (early) and 21 min (late) after intravenous contrast (0·2 mmol kg-1 ). Extracellular volume fraction (ECV) and the GRE and EGE equivalents by T1 mapping were calculated. Focally affected myocardium in myocarditis was defined as increased native T1 compared to remote myocardium.RESULTS:
The GRE equivalent by T1 mapping was higher in myocarditis (n = 19) compared to controls (n = 19) both early (P<0·001) and late (P<0·001). While remote myocardium in myocarditis had higher enhancement relative to skeletal muscle compared to controls early (P = 0·002) and late (P<0·001), ECV of skeletal muscle was lower compared to controls both early (P = 0·03) and late (P = 0·004), and remote myocardial ECV did not differ from controls early (P = 0·37) or late (P = 0·52). The difference in ECV between affected and remote myocardium was higher late compared to early by 5·3 ± 0·7 versus 4·0 ± 0·6%-points (P = 0·002).CONCLUSION:
Quantitative evaluation by T1 mapping shows that early post-contrast imaging does not improve the detection of myocarditis compared to late post-contrast imaging. Focal myocardial abnormalities were more conspicuous late post-contrast.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
/
Imagen por Resonancia Magnética
/
Medios de Contraste
/
Compuestos Heterocíclicos
/
Miocarditis
/
Miocardio
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Physiol Funct Imaging
Asunto de la revista:
FISIOLOGIA
/
PATOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Suecia