Crystal structure of a cytocidal protein from lamprey and its mechanism of action in the selective killing of cancer cells.

Pang, Yue; Gou, Meng; Yang, Kai; Lu, Jiali; Han, Yinglun; Teng, Hongming; Li, Changzhi; Wang, Haina; Liu, Caigang; Zhang, Kejia; Yang, Yongliang; Li, Qingwei

Pang, Yue; Gou, Meng; Yang, Kai; Lu, Jiali; Han, Yinglun; Teng, Hongming; Li, Changzhi; Wang, Haina; Liu, Caigang; Zhang, Kejia; Yang, Yongliang; Li, Qingwei.

Afiliación

Pang Y; College of Life Science, Liaoning Normal University, Dalian, 116081, China.
Gou M; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.
Yang K; College of Life Science, Liaoning Normal University, Dalian, 116081, China.
Lu J; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.
Han Y; College of Life Science, Liaoning Normal University, Dalian, 116081, China.
Teng H; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.
Li C; College of Life Science, Liaoning Normal University, Dalian, 116081, China.
Wang H; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.
Liu C; College of Life Science, Liaoning Normal University, Dalian, 116081, China.
Zhang K; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.
Yang Y; College of Life Science, Liaoning Normal University, Dalian, 116081, China.
Li Q; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.

Cell Commun Signal ; 17(1): 54, 2019 05 27.

Article en En | MEDLINE | ID: mdl-31133022

Asunto(s)

Antineoplásicos/química; Citotoxinas/química; Proteínas de Peces/química; Lampreas/metabolismo; Microdominios de Membrana/efectos de los fármacos; Animales; Antineoplásicos/farmacología; Línea Celular Tumoral; Citotoxinas/farmacología; Proteínas de Peces/farmacología; Proteínas Ligadas a GPI/metabolismo; Humanos; Lectinas/metabolismo; Microdominios de Membrana/metabolismo; Simulación de Dinámica Molecular; Unión Proteica; Esfingomielinas/metabolismo

Palabras clave

Cytotoxic activity; GPI-APs; LIP; Lamprey; Selective recognition

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microdominios de Membrana / Proteínas de Peces / Citotoxinas / Lampreas / Antineoplásicos Tipo de estudio: Screening_studies Límite: Animals / Humans Idioma: En Revista: Cell Commun Signal Año: 2019 Tipo del documento: Article País de afiliación: China

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