Risk detection for high-grade cervical disease using Onclarity HPV extended genotyping in women, ≥21â¯years of age, with ASC-US or LSIL cytology.
Gynecol Oncol
; 154(2): 360-367, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-31160073
ABSTRACT
OBJECTIVES:
There is growing interest in using human papillomavirus (HPV) genotyping as a risk-based triage approach for women with atypical squamous cells-undetermined significance (ASC-US) and low-grade squamous intraepithelial lesions (LSIL) cytology.METHODS:
This analysis includes 2807 subjects with ASC-US or LSIL cytology, ≥21â¯years, from the baseline phase of the Onclarity HPV trial. All women were referred to colposcopy/biopsy. Hierarchical-ranked prevalence and risk values, associated with high-grade cervical disease, were calculated based on extended genotyping.RESULTS:
HPV 16 carried the highest risk for cervical intraepithelial neoplasia grade 2 or worse (≥CIN2) in both the ASC-US and LSIL populations. Risk of ≥CIN3 and ≥CIN2 associated with the other 13 genotypes varied somewhat for women with ASC-US and LSIL, however, HPV 31, 18, 33/58, 51 and 52 appear to comprise an intermediate risk band. Risk associated with HPV 35/39/68, 45, and 56/59/66, in either cytology population, was relatively low and beneath the benchmark threshold risk for immediate colposcopy. Restricting the analysis to women 21-24â¯years, ≥25â¯years, or ≥30â¯years produced similar results.CONCLUSIONS:
HPV genotyping identified multiple risk bands for ≥CIN3 and ≥CIN2 in the ≥21â¯year-old ASC-US and LSIL populations. These results support a 1-year follow-up period to preclude immediate colposcopy for ASC-US or LSIL women positive for the lowest-risk HPV genotypes.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Papillomaviridae
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Tamizaje Masivo
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Infecciones por Papillomavirus
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Células Escamosas Atípicas del Cuello del Útero
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Lesiones Intraepiteliales Escamosas de Cuello Uterino
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
/
Etiology_studies
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Observational_studies
/
Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Gynecol Oncol
Año:
2019
Tipo del documento:
Article