Glutamate as intracellular and extracellular signals in pancreatic islet functions.
Proc Jpn Acad Ser B Phys Biol Sci
; 95(6): 246-260, 2019.
Article
en En
| MEDLINE
| ID: mdl-31189778
ABSTRACT
l-Glutamate is one of the most abundant amino acids in the body and is a constituent of proteins and a substrate in metabolism. It is well known that glutamate serves as a primary excitatory neurotransmitter and a critical neuromodulator in the brain. Recent studies have shown that in addition to its pivotal role in neural functions, glutamate plays many important roles in a variety of cellular functions, including those as intracellular and extracellular signals. In pancreatic islets, glutamate is now known to be required for the normal regulation of insulin secretion, such as incretin-induced insulin secretion. In this review, we primarily discuss the physiological and pathophysiological roles of glutamate as intracellular and extracellular signals in the functions of pancreatic islets.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Islotes Pancreáticos
/
Ácido Glutámico
/
Espacio Intracelular
/
Espacio Extracelular
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Proc Jpn Acad Ser B Phys Biol Sci
Asunto de la revista:
BIOLOGIA
/
FISIOLOGIA
Año:
2019
Tipo del documento:
Article