Identification and characterization of potent and selective inhibitors targeting protein tyrosine phosphatase 1B (PTP1B).

Jin, Jia; Ye, Xiaoqing; Boateng, Derrick; Dai, Kaili; Ye, Fei; Du, Pengfei; Yu, Han

Jin, Jia; Ye, Xiaoqing; Boateng, Derrick; Dai, Kaili; Ye, Fei; Du, Pengfei; Yu, Han.

Afiliación

Jin J; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Hangzhou 310018, China. Electronic address: aukaukauk@163.com.
Ye X; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materta Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Boateng D; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Dai K; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Ye F; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Du P; Department of Endocrinology, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China. Electronic address: pengfei_du@126.com.
Yu H; School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China. Electronic address: hanyu@sit.edu.cn.

Bioorg Med Chem Lett ; 29(16): 2358-2363, 2019 08 15.

Article en En | MEDLINE | ID: mdl-31221555

Asunto(s)

Inhibidores Enzimáticos/farmacología; Proteína Tirosina Fosfatasa no Receptora Tipo 1/antagonistas & inhibidores; Línea Celular; Supervivencia Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Inhibidores Enzimáticos/síntesis química; Inhibidores Enzimáticos/química; Humanos; Modelos Moleculares; Estructura Molecular; Proteína Tirosina Fosfatasa no Receptora Tipo 1/metabolismo; Relación Estructura-Actividad

Palabras clave

Dihydropyridine thione; PTP1B; Selective inhibitors; TCPTP; Type 2 diabetes

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 1 Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article

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