Thiocladospolide E and cladospamide A, novel 12-membered macrolide and macrolide lactam from mangrove endophytic fungus Cladosporium sp. SCNU-F0001.
Fitoterapia
; 137: 104246, 2019 Sep.
Article
en En
| MEDLINE
| ID: mdl-31226284
ABSTRACT
Chemical investigation of the mangrove endophytic fungus Cladosporium sp. SCNU-F0001 resulted in the isolation and identification of a new macrolide compound named thiocladospolide E (1) and a novel macrolide lactam named cladospamide A (2), along with the known cladospolide B (3). The structures were elucidated based on spectroscopic methods, and the absolute configurations were determined by X-ray diffraction and HPLC analysis after chemical derivatization. All compounds were tested for their antibacterial and cytotoxic activity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cladosporium
/
Macrólidos
/
Rhizophoraceae
/
Lactamas
/
Antibacterianos
Límite:
Humans
Idioma:
En
Revista:
Fitoterapia
Año:
2019
Tipo del documento:
Article
País de afiliación:
China