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Comparative research on the metabolism of metoprolol by four CYP2D6 allelic variants in vitro with LC-MS/MS.
Yang, Qingqing; Sun, Jing; Li, Chuan; Zhang, Haizhi; Xu, Weiren; Liu, Changxiao; Zheng, Xuemin.
Afiliación
  • Yang Q; Department of Pharmacology, Tianjin Medical University, Tianjin, 300070, China.
  • Sun J; Department of Pharmacology, Tianjin Medical University, Tianjin, 300070, China.
  • Li C; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China.
  • Zhang H; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China. Electronic address: hzzhang@iccas.ac.cn.
  • Xu W; Department of Pharmacology, Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China. Electronic address: xuwr@tjipr.com.
  • Liu C; Tianjin Center for New Drug Evaluation and Research, State Key Laboratory of Drug Delivery Technology and Pharmaceutics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China.
  • Zheng X; Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China.
J Pharm Biomed Anal ; 174: 479-485, 2019 Sep 10.
Article en En | MEDLINE | ID: mdl-31228851
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Variación Genética / Citocromo P-450 CYP2D6 / Metoprolol Límite: Humans Idioma: En Revista: J Pharm Biomed Anal Año: 2019 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Variación Genética / Citocromo P-450 CYP2D6 / Metoprolol Límite: Humans Idioma: En Revista: J Pharm Biomed Anal Año: 2019 Tipo del documento: Article País de afiliación: China