Acquired amegakaryocytic thrombocytopenia as a rare cause of thrombocytopenia during pregnancy.
BMJ Case Rep
; 12(6)2019 Jun 21.
Article
en En
| MEDLINE
| ID: mdl-31229978
ABSTRACT
A rare case of acquired amegakaryocytic thrombocytopenia (AATP) in a 35-year-old woman who presented with anaemia and thrombocytopenia at 22 weeks gestation. The first diagnostic impression was of an evolving aplastic anaemia; however, the patient was simultaneously diagnosed with severe vitamin B12 deficiency in the setting of vegetarianism. Once the cyanocobalamin deficiency was corrected, a repeat bone marrow biopsy revealed an isolated depletion of megakaryocytes, which suggested the diagnosis of AATP. Supportive care was provided for her anaemia and thrombocytopenia and she delivered a healthy baby girl with a normal platelet count. The patient was subsequently started on romiplostim with steady improvement in her platelet counts. This rare AATP case presentation highlights the importance of a well-structured diagnostic approach to thrombocytopenia during pregnancy and supports the successful use of thrombopoietin agonists for the management of AATP.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Hematológicas del Embarazo
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Púrpura Trombocitopénica
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Trombocitopenia
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Trombopoyetina
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Enfermedades de la Médula Ósea
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Proteínas Recombinantes de Fusión
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Receptores Fc
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
BMJ Case Rep
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos