Aerosol anesthesia increases hypercapnic ventilation and breathlessness in laryngectomized humans.
J Appl Physiol (1985)
; 63(6): 2286-92, 1987 Dec.
Article
en En
| MEDLINE
| ID: mdl-3125140
ABSTRACT
The effect of local anesthetic aerosol inhalation on the ventilatory response and the sensation of breathlessness to CO2 rebreathing was studied in seven healthy male subjects with permanent tracheal stomas after laryngectomy for carcinoma. Inhalation of bupivacaine aerosol sufficient to abolish the cough reflex to mechanical probing below the carina increased the ventilatory response to CO2 in six of seven subjects compared with saline control. This was achieved by an increase in both respiratory frequency (f) and tidal volume (VT) in four subjects, f in one subject, and VT in one subject. All subjects reported that they were more breathless on rebreathing after bupivacaine aerosol. The six subjects who recorded breathlessness with a visual analog scale (VAS) indicated its onset at a lower minute ventilation (VE) and gave higher VAS scores for equivalent levels of VE after threshold. We conclude that the enhanced CO2 sensitivity and breathlessness on rebreathing after airway anesthesia results from altered lower airway receptor discharge.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Bupivacaína
/
Dióxido de Carbono
/
Disnea
/
Hipercapnia
/
Anestesia por Inhalación
/
Laringectomía
Límite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Appl Physiol (1985)
Asunto de la revista:
FISIOLOGIA
Año:
1987
Tipo del documento:
Article
País de afiliación:
Reino Unido