Milk-Derived Amadori Products in Feces of Formula-Fed Infants.
J Agric Food Chem
; 67(28): 8061-8069, 2019 Jul 17.
Article
en En
| MEDLINE
| ID: mdl-31264412
ABSTRACT
Food processing of infant formula alters chemical structures, including the formation of Maillard reaction products between proteins and sugars. We detected early Maillard reaction products, so-called Amadori products, in stool samples of formula-fed infants. In total, four Amadori products (N-deoxylactulosyllysine, N-deoxyfructosyllysine, N-deoxylactulosylleucylisoleucine, N-deoxyfructosylleucylisoleucine) were identified by a combination of complementary nontargeted and targeted metabolomics approaches. Chemical structures were confirmed by preparation and isolation of reference compounds, LC-MS/MS, and NMR. The leucylisoleucine Amadori compounds, which most likely originate from ß-lactoglobulin, were excreted throughout the first year of life in feces of formula-fed infants but were absent in feces of breastfed infants. Despite high inter- and intraindividual differences of Amadori products in the infants' stool, solid food introduction resulted in a continuous decrease, proving infant formula as the major source of the excreted Amadori products.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Alimentación con Biberón
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Productos Finales de Glicación Avanzada
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Fórmulas Infantiles
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Heces
Tipo de estudio:
Clinical_trials
Límite:
Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
J Agric Food Chem
Año:
2019
Tipo del documento:
Article
País de afiliación:
Alemania