Somatic mutations and cell identity linked by Genotyping of Transcriptomes.

Nam, Anna S; Kim, Kyu-Tae; Chaligne, Ronan; Izzo, Franco; Ang, Chelston; Taylor, Justin; Myers, Robert M; Abu-Zeinah, Ghaith; Brand, Ryan; Omans, Nathaniel D; Alonso, Alicia; Sheridan, Caroline; Mariani, Marisa; Dai, Xiaoguang; Harrington, Eoghan; Pastore, Alessandro; Cubillos-Ruiz, Juan R; Tam, Wayne; Hoffman, Ronald; Rabadan, Raul; Scandura, Joseph M; Abdel-Wahab, Omar; Smibert, Peter; Landau, Dan A

Nam, Anna S; Kim, Kyu-Tae; Chaligne, Ronan; Izzo, Franco; Ang, Chelston; Taylor, Justin; Myers, Robert M; Abu-Zeinah, Ghaith; Brand, Ryan; Omans, Nathaniel D; Alonso, Alicia; Sheridan, Caroline; Mariani, Marisa; Dai, Xiaoguang; Harrington, Eoghan; Pastore, Alessandro; Cubillos-Ruiz, Juan R; Tam, Wayne; Hoffman, Ronald; Rabadan, Raul; Scandura, Joseph M; Abdel-Wahab, Omar; Smibert, Peter; Landau, Dan A.

Afiliación

Nam AS; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Kim KT; New York Genome Center, New York, NY, USA.
Chaligne R; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Izzo F; New York Genome Center, New York, NY, USA.
Ang C; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Taylor J; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Myers RM; New York Genome Center, New York, NY, USA.
Abu-Zeinah G; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Brand R; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Omans ND; New York Genome Center, New York, NY, USA.
Alonso A; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Sheridan C; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Mariani M; New York Genome Center, New York, NY, USA.
Dai X; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Harrington E; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Pastore A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cubillos-Ruiz JR; New York Genome Center, New York, NY, USA.
Tam W; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Hoffman R; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Rabadan R; Tri-Institutional MD-PhD Program, Weill Cornell Medicine, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Scandura JM; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Abdel-Wahab O; Richard T. Silver MD Myeloproliferative Neoplasms Center, Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Smibert P; New York Genome Center, New York, NY, USA.
Landau DA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Nature ; 571(7765): 355-360, 2019 07.

Article en En | MEDLINE | ID: mdl-31270458

Asunto(s)

Genotipo; Mutación; Trastornos Mieloproliferativos/genética; Trastornos Mieloproliferativos/patología; Neoplasias/genética; Neoplasias/patología; Transcriptoma/genética; Animales; Antígenos CD34/metabolismo; Calreticulina/genética; Línea Celular; Proliferación Celular; Células Clonales/clasificación; Células Clonales/metabolismo; Células Clonales/patología; Endorribonucleasas/metabolismo; Hematopoyesis/genética; Células Madre Hematopoyéticas/clasificación; Células Madre Hematopoyéticas/metabolismo; Células Madre Hematopoyéticas/patología; Secuenciación de Nucleótidos de Alto Rendimiento/métodos; Humanos; Ratones; Modelos Moleculares; Trastornos Mieloproliferativos/clasificación; FN-kappa B/metabolismo; Neoplasias/clasificación; Células Madre Neoplásicas/citología; Células Madre Neoplásicas/metabolismo; Células Madre Neoplásicas/patología; Mielofibrosis Primaria/genética; Mielofibrosis Primaria/patología; Proteínas Serina-Treonina Quinasas/metabolismo; Análisis de Secuencia de ARN/métodos; Análisis de la Célula Individual/métodos; Respuesta de Proteína Desplegada/genética

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transcriptoma / Genotipo / Mutación / Trastornos Mieloproliferativos / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nature Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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