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Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.
Chaurasia, Bhagirath; Tippetts, Trevor S; Mayoral Monibas, Rafael; Liu, Jinqi; Li, Ying; Wang, Liping; Wilkerson, Joseph L; Sweeney, C Rufus; Pereira, Renato Felipe; Sumida, Doris Hissako; Maschek, J Alan; Cox, James E; Kaddai, Vincent; Lancaster, Graeme Iain; Siddique, Monowarul Mobin; Poss, Annelise; Pearson, Mackenzie; Satapati, Santhosh; Zhou, Heather; McLaren, David G; Previs, Stephen F; Chen, Ying; Qian, Ying; Petrov, Aleksandr; Wu, Margaret; Shen, Xiaolan; Yao, Jun; Nunes, Christian N; Howard, Andrew D; Wang, Liangsu; Erion, Mark D; Rutter, Jared; Holland, William L; Kelley, David E; Summers, Scott A.
Afiliación
  • Chaurasia B; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Tippetts TS; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Mayoral Monibas R; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Liu J; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Li Y; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Wang L; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Wilkerson JL; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Sweeney CR; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Pereira RF; School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015, Brazil.
  • Sumida DH; School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015, Brazil.
  • Maschek JA; Department of Biochemistry and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Cox JE; Department of Biochemistry and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Kaddai V; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Lancaster GI; Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
  • Siddique MM; Faculty of Science, University of Brunei Darussalam, Gadong 1410, Brunei Darussalam.
  • Poss A; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Pearson M; Sciex, Framingham, MA 01701, USA.
  • Satapati S; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Zhou H; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • McLaren DG; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Previs SF; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Chen Y; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Qian Y; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Petrov A; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Wu M; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Shen X; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Yao J; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Nunes CN; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Howard AD; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Wang L; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Erion MD; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
  • Rutter J; Department of Biochemistry and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Holland WL; Howard Hughes Medical Institute, Salt Lake City, UT 84112, USA.
  • Kelley DE; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, UT 84112, USA.
  • Summers SA; Merck Research Laboratories, Merck, Kenilworth, NJ 07033, USA.
Science ; 365(6451): 386-392, 2019 07 26.
Article en En | MEDLINE | ID: mdl-31273070
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxidorreductasas / Resistencia a la Insulina / Ceramidas / Hígado Graso / Proteínas de la Membrana Límite: Animals Idioma: En Revista: Science Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxidorreductasas / Resistencia a la Insulina / Ceramidas / Hígado Graso / Proteínas de la Membrana Límite: Animals Idioma: En Revista: Science Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos