Prospective memory in non-psychotic first-degree relatives of patients with schizophrenia: a meta-analysis.
Neuropsychiatr Dis Treat
; 15: 1563-1571, 2019.
Article
en En
| MEDLINE
| ID: mdl-31289442
ABSTRACT
Prospective memory (PM) could be impaired in the non-psychotic first-degree relatives of patients with schizophrenia. This meta-analysis systematically examined the PM of non-psychotic first-degree relatives of patients with schizophrenia. Both Chinese and English databases were systematically searched for articles from the inception of the databases through November 13, 2018. Case-control studies of PM in non-psychotic first-degree relatives of patients with schizophrenia were included in the analyses. Confidence intervals (CIs) and standardized mean differences (SMDs) were calculated utilizing the random effects model. Four studies (n=268) that compared PM performance between non-psychotic first-degree relatives of patients with schizophrenia (n=136) and healthy controls (n=132) were included. Three studies were rated as "high quality", while the quality of evidence of the three outcomes included in this meta-analysis was moderate. Compared with the healthy controls, the non-psychotic first-degree relatives of patients with schizophrenia showed impairments in overall PM (two studies, n=127; SMD -0.46; 95% CI=-0.82, -0.11, P=0.01; I=0%), event-based PM (EBPM) (four studies, n=268; SMD -0.56; 95% CI=-0.80, -0.31, P<0.00001; I=0%), and time-based PM (TBPM) (four studies, n=268; SMD -0.66; 95% CI=-0.90, -0.41, P<0.00001; I=0%). This meta-analysis demonstrated that the overall PM, EBPM, and TBPM might be impaired in the non-psychotic first-degree relatives of patients with schizophrenia.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Observational_studies
/
Systematic_reviews
Idioma:
En
Revista:
Neuropsychiatr Dis Treat
Año:
2019
Tipo del documento:
Article