Survivors of Ebola Virus Disease Develop Polyfunctional Antibody Responses.
J Infect Dis
; 221(1): 156-161, 2020 01 01.
Article
en En
| MEDLINE
| ID: mdl-31301137
ABSTRACT
Monoclonal antibodies can mediate protection against Ebola virus (EBOV) infection through direct neutralization as well as through the recruitment of innate immune effector functions. However, the antibody functional response following survival of acute EBOV disease has not been well characterized. In this study, serum antibodies from Ebola virus disease (EVD) survivors from Sierra Leone were profiled to capture variation in overall subclass/isotype abundance, neutralizing activity, and innate immune effector functions. Antibodies from EVD survivors exhibited robust innate immune effector functions, mediated primarily by IgG1 and IgA1. In conclusion, development of functional antibodies follows survival of acute EVD.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Inmunoglobulina G
/
Fiebre Hemorrágica Ebola
/
Anticuerpos Neutralizantes
/
Inmunidad Innata
/
Anticuerpos Antivirales
Límite:
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Infect Dis
Año:
2020
Tipo del documento:
Article