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The parmodulin NRD-21 is an allosteric inhibitor of PAR1 Gq signaling with improved anti-inflammatory activity and stability.
Gandhi, Disha M; Rosas, Ricardo; Greve, Eric; Kentala, Kaitlin; D-R Diby, N'Guessan; Snyder, Vladyslava A; Stephans, Allison; Yeung, Teresa H W; Subramaniam, Saravanan; DiMilo, Elliot; Kurtenbach, Khia E; Arnold, Leggy A; Weiler, Hartmut; Dockendorff, Chris.
Afiliación
  • Gandhi DM; Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201-1881, USA.
  • Rosas R; Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201-1881, USA.
  • Greve E; Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201-1881, USA.
  • Kentala K; Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201-1881, USA.
  • D-R Diby N; Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201-1881, USA.
  • Snyder VA; Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201-1881, USA.
  • Stephans A; Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201-1881, USA.
  • Yeung THW; Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201-1881, USA.
  • Subramaniam S; Blood Research Institute, Versiti, Milwaukee, WI 53226, USA.
  • DiMilo E; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin, Milwaukee, WI 53211, USA.
  • Kurtenbach KE; Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201-1881, USA.
  • Arnold LA; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin, Milwaukee, WI 53211, USA.
  • Weiler H; Blood Research Institute, Versiti, Milwaukee, WI 53226, USA; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Dockendorff C; Department of Chemistry, Marquette University, P.O. Box 1881, Milwaukee, WI 53201-1881, USA. Electronic address: christopher.dockendorff@mu.edu.
Bioorg Med Chem ; 27(17): 3788-3796, 2019 09 01.
Article en En | MEDLINE | ID: mdl-31320211
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxazoles / Transducción de Señal / Antiinflamatorios no Esteroideos / Receptor PAR-1 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oxazoles / Transducción de Señal / Antiinflamatorios no Esteroideos / Receptor PAR-1 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos