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Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.
Zhang, Donglu; Dragovich, Peter S; Yu, Shang-Fan; Ma, Yong; Pillow, Thomas H; Sadowsky, Jack D; Su, Dian; Wang, Wei; Polson, Andrew; Khojasteh, S Cyrus; Hop, Cornelis E C A.
Afiliación
  • Zhang D; Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California zhang.donglu@gene.com hop.cornelis@gene.com.
  • Dragovich PS; Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California.
  • Yu SF; Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California.
  • Ma Y; Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California.
  • Pillow TH; Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California.
  • Sadowsky JD; Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California.
  • Su D; Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California.
  • Wang W; Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California.
  • Polson A; Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California.
  • Khojasteh SC; Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California.
  • Hop CECA; Drug Metabolism & Pharmacokinetics (D.Z., Y.M., D.S., W.W., S.C.K., C.E.C.A.H.), Discovery Chemistry (P.S.D., T.H.P.), Translational Oncology (S.-F.Y., A.P.), and Protein Chemistry (J.D.S.), Genentech, South San Francisco, California zhang.donglu@gene.com hop.cornelis@gene.com.
Drug Metab Dispos ; 47(10): 1146-1155, 2019 10.
Article en En | MEDLINE | ID: mdl-31358513
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptor ErbB-2 / Inmunoconjugados / Lectina 2 Similar a Ig de Unión al Ácido Siálico / Antineoplásicos Inmunológicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptor ErbB-2 / Inmunoconjugados / Lectina 2 Similar a Ig de Unión al Ácido Siálico / Antineoplásicos Inmunológicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article