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In vitro Pharmacodynamics and PK/PD in Animals.
Lee, Winnie; Cai, Yiying; Lim, Tze-Peng; Teo, Jocelyn; Chua, Sonja Courtney; Kwa, Andrea Lay-Hoon.
Afiliación
  • Lee W; Singapore General Hospital, Singapore, Singapore.
  • Cai Y; Singapore General Hospital, Singapore, Singapore.
  • Lim TP; Singapore General Hospital, Singapore, Singapore.
  • Teo J; Singapore General Hospital, Singapore, Singapore.
  • Chua SC; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
  • Kwa AL; Singapore General Hospital, Singapore, Singapore. andrea.kwa@duke-nus.edu.sg.
Adv Exp Med Biol ; 1145: 105-116, 2019.
Article en En | MEDLINE | ID: mdl-31364074
ABSTRACT
In the last decade, considerable advancements have been made to identify the pharmacokinetic/pharmacodynamic (PK/PD) index that defines the antimicrobial activity of polymyxins. Dose-fractionation studies performed in hollow-fiber models found that altering the dosing schedule had little impact on the killing or suppression of resistance emergence, alluding to AUC/MIC as the pharmacodynamic index that best describes polymyxin's activity. For in vivo efficacy, the PK/PD index that was the most predictive of the antibacterial effect of colistin against P. aeruginosa and A. baumannii was ƒAUC/MIC.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Polimixinas / Antibacterianos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Adv Exp Med Biol Año: 2019 Tipo del documento: Article País de afiliación: Singapur

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Polimixinas / Antibacterianos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Adv Exp Med Biol Año: 2019 Tipo del documento: Article País de afiliación: Singapur