SLPI in the perfusion solution helps to identify graft quality in kidney transplants.
Biomark Med
; 13(11): 895-906, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-31379196
ABSTRACT
Aim:
It is important to find biomarkers that identify the graft quality in kidney transplantation. Results &methodology:
The level of SLPI in the cold preservation solution was used as a marker to predict early kidney graft function after transplantation. Before transplantation, kidneys were washed and SLPI was measured in the discarded solution. A retrospective analysis showed that patients with delayed graft function or rejection episodes in post-trasplant, had higher SLPI concentrations in the perfusion solution than patients without delayed graft function or rejections. Furthermore, SLPI could discriminate between patients with better or worse estimated glomerular filtration rate among low-risk patients (kidney donor profile index <80). Discussion &conclusion:
These results suggest that the SLPI concentration in the perfusion solutions could be a predictor of short-term organ function and a complement to the kidney donor profile index score.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Perfusión
/
Inhibidor Secretorio de Peptidasas Leucocitarias
/
Riñón
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biomark Med
Asunto de la revista:
BIOQUIMICA
/
MEDICINA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Argentina