Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D<sub>3</sub> receptor ligands.

Chen, Peng-Jen; Taylor, Michelle; Griffin, Suzy A; Amani, Armaghan; Hayatshahi, Hamed; Korzekwa, Kenneth; Ye, Min; Mach, Robert H; Liu, Jin; Luedtke, Robert R; Gordon, John C; Blass, Benjamin E

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D₃ receptor ligands.

Chen, Peng-Jen; Taylor, Michelle; Griffin, Suzy A; Amani, Armaghan; Hayatshahi, Hamed; Korzekwa, Kenneth; Ye, Min; Mach, Robert H; Liu, Jin; Luedtke, Robert R; Gordon, John C; Blass, Benjamin E.

Afiliación

Chen PJ; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 194140, USA.
Taylor M; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.
Griffin SA; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.
Amani A; Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.
Hayatshahi H; Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.
Korzekwa K; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 194140, USA.
Ye M; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 194140, USA.
Mach RH; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Chemistry Building, 231 S. 34th Street, Philadelphia, PA 19104, USA.
Liu J; Department of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.
Luedtke RR; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.
Gordon JC; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 194140, USA.
Blass BE; Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 194140, USA. Electronic address: benjamin.blass@temple.edu.

Bioorg Med Chem Lett ; 29(18): 2690-2694, 2019 09 15.

Article en En | MEDLINE | ID: mdl-31387791

Asunto(s)

Benzamidas/farmacología; Diseño de Fármacos; Piperazinas/farmacología; Receptores de Dopamina D3/metabolismo; Animales; Benzamidas/síntesis química; Benzamidas/química; Relación Dosis-Respuesta a Droga; Ligandos; Microsomas Hepáticos/química; Microsomas Hepáticos/metabolismo; Simulación del Acoplamiento Molecular; Estructura Molecular; Piperazinas/síntesis química; Piperazinas/química; Ratas; Relación Estructura-Actividad

Palabras clave

D(2); D(3); Dopamine receptor; Drug addiction; G-protein coupled receptor (GPCR)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piperazinas / Benzamidas / Diseño de Fármacos / Receptores de Dopamina D3 Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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